
Table of Contents
The Best Acne Supplements
YOUR ULTIMATE GUIDE TO THE TOP PIMPLE SUPPLEMENTS

Inflammatory acne vulgaris, or acne, is a skin issue almost everyone experiences. It’s characterized by blackheads, inflammation, rashes, whiteheads, and sometimes deep lesions. Acne can be classified into three categories: mild, moderate, and bad acne. Most of it occurs on the face, but it can occur elsewhere in the body.
According to the American Academy of Dermatology, multiple factors can cause breakouts. It can be anything from dirt, bacteria, excess oil production, hormones, diet, food intake, skin damage, etc.
While it may feel hopeless to get rid of pimples, don’t fret because there are many treatments available. These treatments can be topical in creams, gels, lotions, and washes. The most common topical treatments are prescription treatments containing tretinoin or antibiotics, such as clindamycin.
They can also be oral and come in the form of pills. A doctor can prescribe you antibiotics such as tetracycline to fight bacteria from within. A prenatal vitamin and birth control pills can be prescribed to you and can help regulate the hormones and improve your condition. For more severe cases, a doctor may also prescribe isotretinoin.
Isotretinoin, such as Accutane, is a potent drug that reduces the size of oil glands and regulates skin cell turnover. While it may sound daunting to go to a certified dermatologist to cure your acne, don’t worry, as there are also over-the-counter options available.
Over-the-counter treatments can help you in many ways, especially if your case isn’t severe and you want to maintain healthy, good-looking skin. In this article, we’ve ranked the best acne pills to improve your condition. Most, if not all, on this list are over-the-counter products that cost a little less than seeking a dermatologist.
Don’t get us wrong. We’re not saying you shouldn’t seek a professional who can provide medical advice, diagnosis, or treatment! We’re just saying that these options may be able to help you without costing you a whole lot for monthly service. Check them out!
WHAT ARE THE BEST SUPPLEMENT FOR ACNE?
LactezinLactezin is our top choice as it's affordable, and easily available nationwide. It contained lactoferrin and antioxidants that keep your skin healthy and glowing! | Puritan’s Pride Zinc for AcneAs its name suggests, the Puritan's Pride Zinc for Acne contains Zinc as its main ingredient. Zinc can boost the immune system and reduces inflammation. | Murad Pure SkinMurad Pure Skin contains vitamin E and A, for a healthy and clearer glow within. |
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LET’S GO OVER EACH SUPPLEMENT
#1: LACTEZIN
“Don’t let acne get in the way!” is one of Lactezin’s taglines that aims to target people fighting long bouts of pimples, particularly in adulthood.
A clinically tested over-the-counter drug, Lactezin’s main active ingredient is Lactoferrin, an iron-binding protein with anti-bacterial and anti-inflammatory properties.
Along with Lactoferrin, other key ingredients of Lactezin are vitamin E and zinc. Such a vitamin is an antioxidant that helps fight free radical skin damage, protects the skin from UV photodamage, and regulates collagen to prevent skin dryness.
On the other hand, zinc is known to be an essential mineral that not only boosts the immune system but also helps heal and rejuvenate the skin.
While it doesn’t have other key supplemental vitamins, such as Vitamin D and B vitamins, it still does the job.
Advised to be taken twice daily, Lactezin claims that it can help lessen pimples and give clearer skin in as early as 2 weeks.
The best part? It’s also really affordable! It is an over-the-counter drug and is not a prescription medication. We’re naming Lactezin as the best pimple supplement to help reduce acne vulgaris, treat acne, and more.
PROS AND CONS OF LACTEZIN
Pros | Cons |
---|---|
✔️ Easy to acquire ✔️ Has lactoferrin ✔️ Affordable | ✖️ Possible reappearance of pimples if not taken as maintenance |
#2: PURITAN’S PRIDE ZINC FOR ACNE
You’ve probably heard by now that zinc is a highly important nutrient that can boost one’s immunity. But did you know that zinc can also help in fighting pimples?
That’s right! This supplement not only makes you stronger but also clears up your skin! This is what Puritan’s Pride Zinc supplement is all about.
Puritan’s Pride claims that their pills are specially formulated to complement acne treatments. It’s made with zinc gluconate, a highly cost-effective form of zinc that reduces inflammation, boasts potent antimicrobial properties, and helps prevent pimple breakouts.
The brand combines zinc with additional skin-saving vitamins such as vitamins A, C, E, and B6 to promote healthy skin cells and give you the ultimate anti-pimple pill.
PROS AND CONS OF PURITAN’S PRIDE
Pros | Cons |
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✔️ Zinc as key ingredient ✔️ Also boosts immune health ✔️ Also contains other vitamins | ✖️ Can be pricey |
#3: MURAD PURE SKIN
Tocopherol is commonly touted as a nutrient that can improve beauty at a cellular level. The skin can easily absorb it, speed up the turnover process, and boost the body’s natural defense against toxins. Murad’s Pure Skin is an acne pill that does precisely that.
With tocopherol as the main ingredient, Murad aims to reduce breakouts from the inside for more precise, healthier-looking skin.
Murad’s drugs are also formulated with vitamin A, which plays a key role in cell specialization and normalizes the production of excess skin cells that can clog pores.
It also has a yellow dock and burdock that act as internal cleansers, blood purifiers, and zinc to reduce skin irritation.
Moreover, the Murad Pure Skin supplement is free from parabens, sulfates, phthalates, and gluten.
Murad Pure Skin is also a supplement that helps improve gut health thanks to its use of postbiotic butyrate, an essential fatty acid.
PROS AND CONS OF MURAD PURE SKIN
Pros | Cons |
---|---|
✔️ Formulated with Vitamin E ✔️ For clearer skin ✔️ Also used as dietary supplements | ✖️ Expensive ✖️ People with vitamin E sensitivity may experience irritation |
#4: Oxecure AcNo Formula
The Oxecure AcNo Formula is a supplement designed to address acne from within by supporting hormone balance and calming inflammation associated with acne.
It contains key nutrients like topical vitamin-derived ingredients, vitamin B, and natural plant extracts that promote healthier, brighter skin.
By targeting the root causes of acne, this supplement helps minimize acne lesions and supports overall skin health, making it suitable for acne patients with inflammatory skin conditions.
The supplement not only aids in clearer skin but also contributes to overall wellness when combined with probiotic-rich foods, fatty acids from fish oil, and a balanced diet.
By addressing acne holistically, Oxecure AcNo Formula aligns with broader health benefits beyond skin care, such as supporting the body’s natural defenses and encouraging hormone balance.
While results may take time, its ability to complement topical treatments and boost the skin barrier makes it a reliable addition to any acne care routine.
PROS AND CONS OF OXECURE ACNO FORMULA
Pros | Cons |
---|---|
✔️ Reduces lesions and calms inflammation effectively ✔️ Enhances skin barrier for brighter, healthier skin ✔️ Supports hormonal balance and minimizes oil production in sebaceous glands | ✖️ Results depend on consistent use and may take time to show noticeable improvements |
#5: VIDA GLOW
Vida Glow marine collagen supplements boost the production of collagen, promoting skin elasticity and firmness, and aiding wound healing.
Regular use improves fine lines, supports healthier skin, and complements skin repair. While it enhances skin health, it doesn’t replace sun protection against sun exposure.
Free from added minerals, it doesn’t contribute to zinc deficiencies or copper deficiency, making it a safe oral supplementation choice.
Vida Glow is an effective option to support healthy, youthful skin and improve skin barrier function, but it works best alongside a balanced diet and comprehensive skin care. I also like that it doesn’t have that fish oil taste to it.
PROS AND CONS OF VIDA GLOW
Pros | Cons |
---|---|
✔️ Boosts collagen production, improving skin elasticity and reducing fine lines ✔️ Has anti-inflammatory effects to prevent acne ✔️ Free from added minerals and too much zinc | ✖️ May not provide significant results for severe skin concerns |
DO ACNE PILLS REALLY WORK?
The phrase “your mileage may vary” when it comes to skincare rings true, as everyone’s skin is different. Some products might not work for you. Some may work. Some products work for you but do not affect others. The same phrase can be applied to acne pills as your skin and nutritional needs differ.
Whether the acne treatment you’re using is prescribed or bought over the counter, it’s still a case of trial and error. Acne pills can work but largely depend on the person’s skin, body, and nutritional needs. For those with increased sebum production with moderate acne, the same products may not work for those with dry skin.
Pills often need a prescription, especially if they are antibiotics. To get prescription pills, you will have to seek a dermatologist, as they can provide medical advice, diagnosis, or treatment. But if your case is only mild to moderate, you may be able to heal your troubles with the use of over-the-counter supplements.
DO ACNE PILLS HAVE SIDE EFFECTS?
As is the case with most, if not all, medication out there, acne pills have side effects as well. Some of the common side effects can include dizziness, an upset stomach, lightheadedness, dry or flaky skin, irritated skin, weight gain, and increased sensitivity to the sun.
The aforementioned effects apply to both oral and topical medications. It’s worth noting that the common side effects are only temporary and will pass over time. However, if the experience persists, it’s best to consult your dermatologist.
There are also severe side effects, however, these are rare. If you’re new at taking acne medication, you may not be aware if you’re allergic to an ingredient and may have an allergic reaction. If you experience rash, swelling of the face, lips, or tongue, severe burning or tingling sensation, throat tightness, and shortness of breath, do seek medical help right away.
FREQUENTLY ASKED QUESTIONS
Which vitamin is best for removing pimples?
There are a lot of ways and products to clear acne in adults fast. According to the Mayo Clinic, one of the methods is the use of topicals that can be used on the entire face or as a spot treatment.
You can use a combination of benzoyl peroxide and antibiotics. Other combinations can include clindamycin with benzoyl peroxide or erythromycin with benzoyl peroxide. Together, they are more effective than topical antibiotics alone.
Azelaic acid is a popular choice as well. It is a naturally occurring acid produced by yeast. Azelaic Acid at 20% is effective in eliminating bacteria.
You can also make use of a chemical peel, such as glycolic acid or retinoic acid. It may help in improving the appearance of your skin when used in combination with medicines.
Lastly, you can use alternative medicine to help reduce acne breakouts and spots. Tea tree oil is one of the most popular choices. A lot of skincare products that target pimples incorporate tea tree oil in their formula.
Which dietary supplements are best for acne skin?
We recommend taking a supplement that contains zinc for skin prone to acne. Zinc has been shown to help reduce inflammation and regulate oil, both of which are important factors in the development of acne.
Additionally, taking a probiotic supplement can also help improve overall skin health, as it can help regulate the balance of bacteria in the gut and reduce inflammation throughout the body.
It’s important to note, however, that while supplements can be helpful, they should not be relied on as the sole solution for acne-prone skin. A balanced diet, regular exercise, and a consistent skincare routine that includes gentle cleansing, exfoliation, and moisturization are also essential.
If you have persistent acne or other skin concerns, it’s always best to consult with a dermatologist for personalized advice and treatment options.
Which vitamins are good for skin health?
For skin prone to acne or excess sebum production, vitamin A and vitamin C capsules can be highly effective. This fat-soluble vitamin helps regulate sebum production, reduce inflammation, and promote the turnover of dead skin cells, preventing clogged pores and breakouts.
Preformed vitamin A, found in supplements, can deliver these benefits efficiently. However, high doses of vitamin A can be toxic and lead to serious side effects, so it’s essential to follow the recommended dosage and consult a healthcare professional before starting an oral vitamin regimen. Always consult a healthcare professional before starting an oral vitamin regimen.
In addition to vitamin A, a balanced multivitamin that includes vitamin C, B vitamins (such as pantothenic acid), and vitamin D can further enhance skin health. Vitamin C, found in citrus fruits, acts as a powerful antioxidant, protecting the skin from free radical damage and supporting collagen synthesis.
Vitamin D helps maintain healthy skin and immunity, while B vitamins may help balance hormones and support the skin’s overall appearance. Incorporating these vitamins into your diet or supplementation routine can contribute to a healthier, more radiant complexion.
What are the best pills for hormonal acne treatment?
I would recommend considering birth control pills for hormonal acne. Hormonal acne is caused by an imbalance of hormones in the body, specifically an excess of androgens like testosterone, which can stimulate the production of oil and contribute to pore clogging and breakouts.
Some birth control pills, such as those that contain a combination of estrogen and progestin, can help regulate hormone levels and reduce the severity of hormonal acne. However, it’s important to note that birth control pills can have potential side effects, so it’s important to discuss this option with a healthcare professional to determine if it’s right for you.
In addition to birth control pills, some supplements like Vitamin C can help regulate hormonal imbalances and reduce the severity of hormonal acne. For example, supplements containing saw palmetto, which is a natural anti-androgen, may help reduce excess testosterone levels in the body.
What vitamins should I avoid with severe acne?
There are certain vitamins and supplements that you may want to avoid if you have acne.
First and foremost, you should avoid taking high dosages of vitamin B12, as some studies have suggested that it may contribute to breakouts. Vitamin B12 is an essential nutrient that is important for many bodily functions, but taking high dosages of supplements can disrupt the balance of bacteria in the gut, which can lead to an overgrowth of acne-causing bacteria.
Similarly, some studies have suggested that taking high dosages of iodine supplements may also contribute to breakouts. Iodine is a mineral that is essential for thyroid function, but taking too much can cause the skin to become inflamed and irritated.
Finally, it’s important to note that while supplements can help maintain overall health and wellness, they should not be relied on as the sole solution for skin prone to acne. A balanced diet, regular exercise, and a consistent skincare routine that includes gentle cleansing, exfoliation, and moisturization are also essential.
If you have persistent acne or other skin concerns, it’s always best to consult with a dermatologist or healthcare provider for personalized advice and treatment options.
What is the most effective pill for acne?
The most effective pill for acne is isotretinoin (Accutane), prescribed for severe or persistent acne, though hormonal options like oral contraceptives or spironolactone can also be effective for certain cases. Always consult a dermatologist.
CONCLUSION
We hope that these products will be able to support you in clearing up your acne and achieving your skin goals! Always remember that your mileage may vary, and what works for you may not work for others, or vice versa. And when in doubt, seek your dermatologist. Stay safe, and stay beautiful!

Editor’s Choice
LACTEZIN
Don’t let pimples and breakouts drag your self-esteem down and stop you from doing your thing as acne treatments have become easier to acquire now. One of the best over-the-counter treatment options to try out is Lactezin.
This medicine is formulated with lactoferrin, an iron-binding protein that can get rid of bacteria and can reduce inflammation.
Aside from lactoferrin, Lactezin also contains vitamin E and zinc, two nutrients that can aid in achieving better skin and an even stronger immune system.
For an affordable price, Lactezin claims that it can help clear pimples in as early as 2 weeks.

Ira Arellano graduated with a degree in Multimedia Arts from the De La Salle-College of Saint Benilde. When she’s not busy writing, Ira uses her remaining free time fawning over groups with too many members, reading three books simultaneously, crying over animated shows and fictional people, and being salty over her lack of gacha luck.